Which word describes a large-scale slaughter or destruction?

The term "Holocaust" is used to describe a large-scale slaughter or destruction, particularly in historical contexts referring to the systematic extermination of Jews and others during World War II. It conveys a sense of catastrophic loss and mass death, making it the precise choice for depicting extensive devastation or cruelty.

In contrast, the other options do not convey the same meaning. "Impervious" refers to being unaffected or resistant to something, "Jeopardy" indicates a state of being in danger or risk, and "Nostalgia" describes a sentimental longing for the past. Each of these words relates to different themes and does not encompass the gravity or magnitude of destruction that the word "Holocaust" implies.